Stroke Part II: Clinical manifestations and pathogenesis: Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab) (Handbook of Clinical Neurology)

Book Details

Title	Stroke, Part II: Clinical Manifestations and Pathogenesis
Editor	Marc Fisher
Series Editors	Michael J. Aminoff, François Boller, Dick F. Swaab
Publisher	Elsevier
Year	2008
Edition	1st Edition
Language	English
Pages	592
ISBN	9780444520043
Genre	Neurology, Clinical Medicine
Series	Handbook of Clinical Neurology, Volume 93
Size	38.2 MB
Extension	PDF

Summary

Stroke, Part II: Clinical Manifestations and Pathogenesis is the ninety-third volume of the prestigious Handbook of Clinical Neurology series, published by Elsevier in 2008. Edited by Dr. Marc Fisher, a leading figure in cerebrovascular research, this volume represents the second installment in a three-part comprehensive treatment of stroke within the handbook series [citation:2]. Unlike general neurology textbooks that treat stroke as a single entity, this work is dedicated entirely to the nuanced clinical presentations and underlying pathological mechanisms of cerebrovascular disease. It serves as an authoritative source of reference for clinicians, researchers, and trainees who require a deep understanding of how strokes manifest across different vascular territories and patient populations.

The volume is organized into two major sections that reflect its dual focus. The first section, devoted to the manifestations of stroke, covers the topographic classification of ischemic stroke, transient ischemic attacks, medical complications of acute stroke, anterior and posterior circulation syndromes, lacunar syndromes, hemorrhagic stroke syndromes, neuro-ophthalmologic manifestations, post-stroke seizures, stroke-related psychiatric disorders, vascular dementia, silent cerebral infarcts, and spinal strokes [citation:2]. The second section addresses the causes of stroke, examining extracranial and intracranial atheroma, cardio-embolic stroke, cervical artery dissections, intracerebral and subarachnoid hemorrhage, cerebral venous thrombosis, drug-related stroke, migraine and headache associations, infections, vasculitis, hematological disorders, and rare causes of cerebrovascular disease [citation:2]. This dual structure ensures that readers can approach stroke from both a syndromic and an etiologic perspective.

What distinguishes this volume from a standard textbook is its emphasis on the pathophysiological basis of clinical findings. The chapters are written by specialists who bridge the gap between bench research and bedside practice, explaining not only what clinicians observe but why those observations occur at the level of vascular anatomy, biochemistry, and cellular injury. Topics such as the ischemic penumbra, the evolution of diffusion-weighted imaging lesions, and the biochemical cascades that follow cerebral ischemia are treated with a depth that reflects the dramatic advances made in stroke research during the preceding two decades . This translational approach helps practitioners diagnose more accurately, anticipate complications, and tailor management strategies to the specific mechanism of a patient's stroke.

The primary readership for this volume consists of neurologists, neurology residents, stroke fellows, and neuroscience researchers [citation:2]. Clinicians in related specialties—including neuroradiology, vascular surgery, and critical care medicine—will also find it valuable for understanding the neurological consequences of cerebrovascular disease. While the book is not intended for lay readers or general medical students, it serves as an essential reference for anyone whose work involves the diagnosis, treatment, or investigation of stroke. The chapters on rare causes and unusual presentations are particularly useful for practitioners who encounter diagnostic dilemmas, while the sections on common syndromes provide a solid foundation for routine clinical decision-making.

As part of the Handbook of Clinical Neurology, this volume benefits from the series' reputation for scholarly rigor and editorial consistency [citation:5]. Dr. Fisher's expertise as a translational researcher and longtime editor-in-chief of the journal Stroke ensures that the content reflects both laboratory advances and clinical realities [citation:4]. The book remains a standard reference in medical libraries and neurology departments, valued for its comprehensive coverage and its ability to explain complex cerebrovascular concepts in a clinically actionable manner. For those seeking a definitive guide to the clinical manifestations and pathogenesis of stroke, this volume stands as an indispensable resource.

Key Features

• The volume is part of the Handbook of Clinical Neurology series and constitutes Volume 93, dedicated entirely to the clinical manifestations and pathogenesis of stroke [citation:2].
• It is organized into two major sections: one covering the manifestations of stroke across vascular territories and clinical syndromes, and another addressing the diverse causes of cerebrovascular disease.
• The section on manifestations includes detailed chapters on anterior circulation syndromes, posterior circulation strokes, lacunar syndromes, and hemorrhagic stroke syndromes [citation:2].
• It covers neuro-ophthalmologic manifestations, post-stroke seizures, stroke-related psychiatric disorders, and vascular dementia, areas often underrepresented in general neurology texts.
• The section on causes examines cardio-embolic stroke, cervical artery dissections, cerebral venous thrombosis, vasculitis, hematological disorders, and rare causes of stroke [citation:2].
• The volume includes chapters on special topics such as illicit drug use and stroke, migraine and headache associations, infections, and stroke related to systemic illness and complicated surgery [citation:2].
• It is edited by Marc Fisher, a professor of neurology and radiology who led a stroke modeling laboratory for 25 years and served as editor-in-chief of the journal Stroke from 2010 to 2020 [citation:4].
• The series editors are Michael J. Aminoff, François Boller, and Dick F. Swaab, ensuring editorial consistency and scholarly rigor across the Handbook of Clinical Neurology [citation:5].
• The book provides a translational perspective, linking pathophysiological mechanisms to clinical presentation and management decisions.
• It includes coverage of "silent" cerebral infarcts and microbleeds, reflecting contemporary understanding of cerebrovascular disease beyond acute symptomatic events [citation:2].
• The volume is designed as a reference for clinicians, with chapters structured to facilitate quick consultation while providing sufficient depth for comprehensive study.
• It addresses the dramatic changes in stroke care that occurred in the decades before publication, including advances in neuroimaging, prevention, and acute intervention .
• The book is published by Elsevier, a leading medical and scientific publisher, and is available in both print and electronic formats.

About Author

Dr. Marc Fisher is a Professor of Neurology and Radiology at the University of Massachusetts Medical School in Worcester, Massachusetts, where he spent 36 years before retiring in 2014 [citation:4]. He holds an MD and has had a long career as a translational and clinical researcher in the stroke field. For 25 years, he led a stroke modeling laboratory focused on using MRI technology to evaluate the ischemic penumbra and the effects of various therapies on the evolution of ischemic injury. He has trained more than 25 research fellows from around the world, many of whom now hold prestigious academic positions [citation:4].

Dr. Fisher has published more than 330 peer-reviewed papers with an h-index of 80, and he has participated in numerous clinical trials as a principal investigator or steering committee member [citation:4]. He organized the influential STAIR (Stroke Treatment and Academic Roundtable) meetings, which established recommendations for preclinical modeling practices in ischemic stroke and for clinical trial design [citation:13]. He served as Editor-in-Chief of the journal Stroke from 2010 to 2020 and continues as a senior consulting editor. He is currently a part-time member of the neurology faculty at Beth Israel Deaconess Medical Center in Boston and a Professor of Neurology (part-time) at Harvard Medical School, where he continues to see patients and teach residents and stroke fellows [citation:4].

Related Books

• Stroke, Part I: Basic and Epidemiological Aspects — Marc Fisher (Editor)
• Stroke, Part III: Investigation and Management — Marc Fisher (Editor)
• Handbook of Clinical Neurology: Neuroimaging, Part I — Joseph C. Masdeu and R. Gilberto Gonzalez (Editors)
• Warlow's Stroke: Practical Management — Graeme Hankey, et al.
• Caplan's Stroke: A Clinical Approach — Louis R. Caplan
• Stroke: Pathophysiology, Diagnosis, and Management — James C. Grotta, et al.
• Bradley's Neurology in Clinical Practice — Robert B. Daroff, et al.
• Localization in Clinical Neurology — Paul W. Brazis, et al.

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FAQ

Q : Is this volume a standalone book or part of a larger series?

R : Stroke, Part II is Volume 93 of the Handbook of Clinical Neurology, a long-running and highly respected series that covers the entire field of clinical neurology [citation:2][citation:5]. It is the second of three volumes dedicated specifically to stroke, with Part I covering basic and epidemiological aspects and Part III addressing investigation and management. While the volume can be used independently as a reference on stroke manifestations and pathogenesis, readers seeking comprehensive coverage of cerebrovascular disease will benefit from consulting all three parts. The series editors are Michael J. Aminoff, François Boller, and Dick F. Swaab.

Q : Who should read this book?

R : The primary audience includes neurologists, neurology residents, stroke fellows, and neuroscience researchers [citation:2]. Clinicians in related fields such as neuroradiology, vascular surgery, and critical care medicine will also find it valuable for understanding the neurological consequences of stroke. The book assumes a solid foundation in clinical neurology and is not intended for medical students or lay readers. Practitioners who encounter diagnostic dilemmas will particularly appreciate the chapters on rare causes and unusual presentations, while those seeking a systematic review of common stroke syndromes will find the first section indispensable.

Q : What distinguishes this volume from a general stroke textbook?

R : Unlike general stroke textbooks that attempt to cover the entire field in a single volume, this book focuses exclusively and in depth on the clinical manifestations and pathogenesis of stroke. This narrow scope allows for detailed coverage of topics that often receive only cursory treatment elsewhere, such as neuro-ophthalmologic manifestations, post-stroke psychiatric disorders, silent cerebral infarcts, and rare causes of cerebrovascular disease [citation:2]. The chapters are written by specialists who emphasize the pathophysiological basis of clinical findings, helping readers understand not just what to look for but why it occurs. This translational approach is a hallmark of the Handbook of Clinical Neurology series.

Q : What is Dr. Marc Fisher's expertise in the field of stroke?

R : Dr. Marc Fisher is a highly respected stroke researcher and clinician who spent 36 years at the University of Massachusetts Medical School, where he led a stroke modeling laboratory for 25 years [citation:4]. He organized the influential STAIR meetings that established recommendations for preclinical stroke research and clinical trial design [citation:13]. He served as Editor-in-Chief of the journal Stroke from 2010 to 2020 and has published more than 330 peer-reviewed papers with an h-index of 80. He is currently a Professor of Neurology (part-time) at Harvard Medical School and a part-time member of the neurology faculty at Beth Israel Deaconess Medical Center.

Q : Does the book cover both ischemic and hemorrhagic stroke?

R : Yes, the volume addresses both ischemic and hemorrhagic stroke, though the emphasis reflects the relative frequency of ischemic stroke in clinical practice. The section on manifestations includes chapters on hemorrhagic stroke syndromes, specifically the clinical manifestations of intracerebral and subarachnoid hemorrhage [citation:2]. The section on causes includes separate chapters on intracerebral hemorrhage and subarachnoid hemorrhage, as well as cerebral venous thrombosis. The coverage of ischemic stroke is more extensive, including anterior and posterior circulation syndromes, lacunar syndromes, and cardio-embolic stroke, which is consistent with the epidemiology of cerebrovascular disease.

Q : Are the chapters written by multiple authors or by Dr. Fisher alone?

R : Like most volumes in the Handbook of Clinical Neurology series, this book is an edited collection with chapters contributed by multiple specialists in the field. Dr. Marc Fisher serves as the volume editor, responsible for the overall structure, selection of topics, and editorial consistency [citation:2]. This multi-author approach brings together expertise from different institutions and subspecialties, ensuring that each topic is addressed by someone with direct clinical or research experience in that area. The series editors provide additional oversight to maintain the high standards of the handbook.

Q : Is the book still relevant given advances in stroke care since 2008?

R : While stroke care has continued to evolve since the book's publication in 2008—particularly in areas such as endovascular thrombectomy and advanced neuroimaging—the fundamental clinical descriptions and pathophysiological mechanisms it covers remain largely valid. The topographic classification of stroke syndromes, the clinical features of anterior and posterior circulation strokes, and the principles of stroke etiology do not change rapidly. The book remains a valuable reference for understanding the clinical presentation of stroke and the reasoning behind diagnostic and management decisions. Readers should supplement it with more recent literature for the latest therapeutic recommendations.

Q : What is the significance of the "silent" cerebral infarcts and microbleeds chapter?

R : The inclusion of a chapter on "silent" cerebral infarcts and microbleeds reflects the growing recognition that cerebrovascular disease often exists without producing acute clinical symptoms [citation:2]. These findings, typically discovered incidentally on neuroimaging performed for other reasons, have important implications for future stroke risk and cognitive decline. The chapter addresses a topic that is increasingly relevant as imaging technology becomes more sensitive and as clinicians recognize that "silent" does not mean benign. This forward-looking coverage distinguishes the volume from older stroke texts that focused exclusively on symptomatic events.