| Author | Andrea Mozzarelli, Stefano Bettati |
| Publisher | Wiley |
| Year | 2011 |
| Language | English |
| Pages | 476 |
| Size | 3.92 MB |
| Extension |
Summary
"Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood" offers a rich and detailed examination of the science and clinical implications behind oxygen-carrying blood substitutes. The book provides in-depth coverage of the molecular basis of oxygen binding and transport in hemoglobin, the development of hemoglobin-based oxygen carriers (HBOCs), and the challenges associated with their use in transfusion medicine. Readers are guided through complex biochemical pathways, physiological relevance, and pharmacokinetics of oxygen delivery systems—both natural and synthetic. With contributions from leading experts, the text also addresses regulatory, manufacturing, and safety issues, making it an invaluable resource for biomedical researchers, healthcare professionals, and students involved in transfusion science, biochemistry, and pharmaceutical biotechnology.
Key Features
- Comprehensive analysis of hemoglobin structure, function, and oxygen transport mechanisms
- Detailed discussion of hemoglobin-based oxygen carriers and perfluorocarbon emulsions
- In-depth examination of biochemical and physiological implications of artificial blood
- Up-to-date overview of clinical trials, regulatory concerns, and product development
- Insight into design strategies for safer and more efficient oxygen therapeutics
- Written by a multidisciplinary team of international experts in the field
About Author
Andrea Mozzarelli is a professor of biochemistry at the University of Parma, Italy, with decades of experience in protein structure and function, particularly hemoglobin and allosteric mechanisms. His research combines structural biology, spectroscopy, and computational methods to explore protein-ligand interactions.
Stefano Bettati, also affiliated with the University of Parma, specializes in the biophysics of macromolecular systems, with a focus on oxygen-binding proteins and their application in therapeutics. Together, they have co-authored multiple papers and are recognized as thought leaders in the field of biochemical pharmacology.
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Frequently Asked Questions
Q: What can I learn by reading this book?
A: You will gain deep insight into the structure and function of oxygen-carrying compounds, the development of blood substitutes, and their applications in clinical and emergency medicine.
Q: This book is suitable for beginners?
A: While the book provides foundational background, it is best suited for advanced students, researchers, and professionals in biochemistry, pharmacology, and medical sciences.
Q: This book is recommended for professionals?
A: Absolutely. This is a valuable reference for medical researchers, clinical practitioners, pharmaceutical developers, and academic instructors interested in transfusion science and oxygen therapeutics.
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