| Title | Biology at the Single-Molecule Level |
| Author(s) | S.H. Leuba, J. Zlatanova |
| Publisher | Pergamon |
| Year | 2001 |
| Edition | 1st Edition |
| Language | English |
| Pages | 110 pages |
| ISBN | 9780080438950 |
| Genre / Domain | Science, Biology, Biophysics, Biochemistry |
| Series | Unknown |
| Size | 18.81 MB |
| Extension |
Summary
Biology at the Single-Molecule Level, edited by S.H. Leuba and J. Zlatanova, represents a landmark publication as the first book exclusively dedicated to the emerging field of single-molecule biochemistry and molecular biology. Published in 2001, this volume was conceived at a time when the ability to observe and manipulate individual biological molecules was revolutionizing our understanding of life's fundamental processes. The editors assembled a distinguished group of contributors, each chosen for their significant and pioneering contributions to the field, to provide a focused and insightful overview of this new frontier in biological research.
The book is structured to highlight the biological insights gained from single-molecule approaches, rather than serving as a comprehensive technical manual. It emphasizes the types of fundamental biological problems that can be uniquely addressed by these techniques, including the study of molecular heterogeneity, the real-time observation of molecular dynamics, and the direct measurement of forces and interactions at the single-molecule level. The chapters explore a diverse range of topics, from the mechanical properties of DNA and chromatin to the functioning of molecular motors and the dynamics of protein folding, showcasing the power of single-molecule methods to reveal phenomena hidden in traditional ensemble measurements.
A key strength of this volume is its focus on the biological questions, making it accessible to a broad audience of biologists and biochemists who may be less familiar with the physical techniques. The authors expertly bridge the gap between the technical complexities of single-molecule experimentation and the biological significance of the results obtained. This approach provides readers with a clear understanding of how these powerful new tools can be applied to answer long-standing questions and open up entirely new areas of inquiry, such as the characterization of transient intermediates and the mapping of energy landscapes for biological processes.
Targeted at researchers and advanced students in biochemistry, molecular biology, biophysics, and related fields, this book serves as an essential introduction and reference for those entering this exciting area of study. Its concise and authoritative chapters make it an ideal starting point for anyone seeking to understand the potential of single-molecule techniques in biology. The book's emphasis on biological applications ensures its relevance to a wide range of life science disciplines, from enzymology and structural biology to cellular mechanics and gene regulation.
As a seminal work in the field, Biology at the Single-Molecule Level has earned a lasting place in the scientific literature. It not only captured the state of the art at the turn of the millennium but also laid the groundwork for the explosive growth of single-molecule biology that has occurred since. Its publication by Pergamon, a respected scientific publisher, and the expertise of its editors and contributors, make it a highly cited and influential resource that continues to inspire and guide researchers in their pursuit of understanding biology at its most fundamental level.
Key Features
- Represents the first book dedicated exclusively to single-molecule biology and biochemistry.
- Features contributions from pioneering researchers who have made significant contributions to the field.
- Focuses on the biological problems that can be addressed using single-molecule techniques.
- Covers a wide range of topics, including DNA mechanics, chromatin structure, protein folding, and molecular motors.
- Emphasizes the biological insights gained from single-molecule approaches.
- Serves as an accessible introduction for biologists and biochemists new to the field.
- Provides a comprehensive overview of the state-of-the-art in single-molecule biology at the time of publication.
- Highlights the potential of single-molecule techniques to reveal heterogeneity and transient states in biological systems.
- Edited by leading authorities in the field of single-molecule research.
- Published as a hardcover volume by Pergamon, ensuring lasting reference quality.
About the Editors
S.H. Leuba is a prominent researcher in the field of single-molecule biophysics. Her work has focused on the structural and dynamic properties of chromatin, using techniques such as atomic force microscopy and optical tweezers. She has made significant contributions to our understanding of how DNA packaging and organization are regulated at the molecular level.
J. Zlatanova is a distinguished scientist known for her extensive research in chromatin structure and function. She has pioneered the application of single-molecule techniques to study the dynamics of DNA-protein interactions and the mechanical properties of chromatin fibers. Her work has provided crucial insights into the mechanisms of gene regulation and DNA repair.
Related Books
- Single-Molecule Biophysics: Experiment and Theory — T. Ando, H. S. Yoon
- Single Molecule Spectroscopy in Chemistry, Physics and Biology — A. Gräslund, R. Rigler, J. Widengren
- Handbook of Single Molecule Fluorescence Spectroscopy — C. Gell, D. Brockwell, A. Smith
- Biophysics: Searching for Principles — William Bialek
- Molecular Biology of the Gene — J.D. Watson, T.A. Baker, S.P. Bell, A. Gann, M. Levine, R. Losick
- Methods in Molecular Biophysics: Structure, Dynamics, Function — I.N. Serdyuk, N.R. Zaccai, G. Zaccai
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Frequently Asked Questions
Q : What is the main focus of "Biology at the Single-Molecule Level"?
R : This is the first book dedicated exclusively to single-molecule biochemistry and molecular biology. It focuses on the biological problems that can be addressed using single-molecule techniques, emphasizing the insights gained rather than the technical details of the methods themselves.
Q : Who are the editors of this book?
R : The book is edited by S.H. Leuba and J. Zlatanova, both prominent researchers known for their contributions to single-molecule biophysics and the study of chromatin structure and dynamics.
Q : What topics are covered in the book?
R : The book covers a wide range of topics, including DNA mechanics, chromatin structure, protein folding, molecular motors, and the dynamics of biological macromolecules at the single-molecule level.
Q : Is this book suitable for researchers new to the field of single-molecule biology?
R : Yes, the book is designed to be accessible to biologists and biochemists who may be less familiar with the physical techniques, as it emphasizes the biological questions and the significance of the results obtained.
Q : What is the publication date and publisher of this book?
R : The book was published in 2001 by Pergamon, a respected scientific publisher known for its high-quality academic works.
Q : What distinguishes this book from other publications on single-molecule techniques?
R : Unlike many technical handbooks, this volume focuses specifically on the biological applications and the new types of insights that single-molecule methods provide, making it a valuable resource for understanding the biological relevance of these techniques.
Q : What is the significance of this book in the field of molecular biology?
R : As the first book of its kind, it played a pivotal role in establishing the field of single-molecule biology and has served as a foundational reference for researchers exploring the behavior of individual biological molecules.
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