| Title | Understanding DNA: The Molecule and How It Works |
| Author(s) | Chris R. Calladine, Horace Drew, Ben Luisi, Andrew Travers |
| Publisher | Academic Press |
| Year | 2004 |
| Edition | 3rd Edition |
| Language | English |
| Pages | 334 pages |
| ISBN | 9780121550899 |
| Genre / Domain | Science, Biology, Genetics, Molecular Biology |
| Series | Unknown |
| Size | 6.80 MB |
| Extension |
Summary
Understanding DNA: The Molecule and How It Works, now in its third edition, stands as a definitive guide to the structure and function of the molecule that encodes all life on Earth. Authored by a team of distinguished experts including Chris R. Calladine, Horace Drew, Ben Luisi, and Andrew Travers, this book has been completely revised and updated to reflect the latest advances in our understanding of DNA. It offers a step-by-step exploration of how DNA forms specific structures, the characteristics of these structures, and their profound impact on the biological processes of transcription and replication, making it an indispensable resource for anyone seeking a deep understanding of this fundamental molecule.
The book is methodically organized to guide the reader from the basic chemical units of DNA to the complexities of the double helix and its various forms. It provides a thorough overview of the methods used to investigate DNA structure, including X-ray crystallography and nuclear magnetic resonance spectroscopy. The text delves into the intricacies of DNA supercoiling, the organization of DNA in chromatin, and the crucial role of nucleosomes in gene regulation. The authors skillfully connect these structural features to their functional implications, explaining how the molecule's architecture dictates its interactions with proteins and its ability to store and transmit genetic information.
One of the book's greatest strengths is its clarity and accessibility. Written in an engaging and concise manner, it demystifies complex concepts without sacrificing scientific rigor. The third edition features over 130 illustrations, many in full color, which serve to illuminate the structural principles discussed in the text. Each chapter concludes with exercises and references for further reading, encouraging readers to deepen their understanding and engage actively with the material. This pedagogical approach makes the book an effective learning tool for both students and independent learners.
Targeted at a broad audience, Understanding DNA is an essential resource for undergraduate and graduate students in molecular biology, biochemistry, and genetics. It is also highly valuable for researchers in these fields who wish to solidify their understanding of DNA structure. Furthermore, the book is an excellent introduction for scientists from related disciplines, such as chemistry or physics, who are entering the field of molecular biology. Its comprehensive coverage and clear explanations ensure that readers from various backgrounds can grasp the essential principles of DNA structure and function.
As a classic text in its field, Understanding DNA has earned a well-deserved reputation for its clarity, depth, and authoritative presentation. The third edition builds upon this legacy, incorporating the most current research and perspectives. The combined expertise of the authors, who are leaders in the study of DNA structure and function, guarantees the accuracy and relevance of the content. This book remains a vital and enduring resource for anyone seeking to understand the molecule that lies at the heart of all biological systems.
Key Features
- Provides a comprehensive and accessible explanation of DNA structure and function.
- Completely revised and updated third edition incorporating the latest scientific advances.
- Features over 130 illustrations, including full-color diagrams, to enhance understanding.
- Describes the basic units of DNA and how they form the double helix.
- Covers the various types of DNA double helices and their biological significance.
- Explains the methods used to investigate DNA structure, including X-ray crystallography and NMR.
- Discusses the role of DNA supercoiling and chromatin organization in gene regulation.
- Includes exercises and further readings to reinforce learning and encourage exploration.
- Written in a clear, engaging, and concise style suitable for students and researchers alike.
- Authored by a team of leading experts in the field of DNA research.
- Serves as an essential resource for molecular biology, biochemistry, and genetics students.
- Valuable for experienced researchers seeking a deeper understanding of DNA.
- Published by Academic Press, ensuring high-quality scientific content.
About the Authors
Chris R. Calladine is a Professor of Structural Engineering at the University of Cambridge, whose research interests include the structural mechanics of DNA and protein-DNA complexes. He has made significant contributions to our understanding of the mechanical properties of DNA and its role in biological processes.
Horace Drew is a researcher in the field of molecular biology, with a focus on DNA structure and its interactions with proteins. He has published extensively on the physical properties of DNA and the mechanisms of DNA recognition by proteins.
Ben Luisi is a Professor of Molecular Biology at the University of Cambridge. His research focuses on the structure and function of macromolecular complexes involved in gene expression, particularly the interactions between DNA and regulatory proteins.
Andrew Travers is a researcher in the field of chromatin structure and function. He has made important contributions to our understanding of how DNA is organized in the cell nucleus and how this organization affects gene expression.
Related Books
- Molecular Biology of the Gene — James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick
- DNA: The Secret of Life — James D. Watson, Andrew Berry
- The Double Helix: A Personal Account of the Discovery of the Structure of DNA — James D. Watson
- Lewin's Genes XII — Jocelyn E. Krebs, Elliott S. Goldstein, Stephen T. Kilpatrick
- Biochemistry — Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto, Lubert Stryer
- Molecular Biology: Principles and Practice — Michael M. Cox, Jennifer Doudna, Michael O'Donnell
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Frequently Asked Questions
Q : What is the main focus of "Understanding DNA: The Molecule and How It Works"?
R : This book provides a comprehensive and accessible explanation of DNA structure and function, covering everything from the basic chemical units to the complex biological processes of transcription and replication.
Q : Who are the authors and what are their qualifications?
R : The book is authored by a team of distinguished experts: Chris R. Calladine (Professor of Structural Engineering), Horace Drew, Ben Luisi (Professor of Molecular Biology), and Andrew Travers. They are all leaders in the field of DNA research.
Q : What is the edition and publication year of this book?
R : This is the third edition, published in 2004 by Academic Press, which has been completely revised and updated to incorporate the latest advances in our understanding of DNA.
Q : What topics are covered in the book?
R : The book covers the basic units of DNA, the formation of the double helix, various types of DNA structures, methods for investigating DNA structure, DNA supercoiling, chromatin organization, and the role of DNA in transcription and replication.
Q : Is this book suitable for beginners in molecular biology?
R : Yes, the book is written in a clear, engaging, and concise manner, making it accessible for students and newcomers from other fields, while also being valuable for experienced researchers seeking a deeper understanding.
Q : Does the book include illustrations and study aids?
R : Yes, the book features over 130 illustrations, many in full color, along with exercises and further readings at the end of each chapter to enhance student comprehension and encourage further study.
Q : What are the key features of the third edition?
R : The third edition has been completely revised and expanded to incorporate the latest scientific advancements, with new information on the structural and functional aspects of DNA, making it an up-to-date and essential resource.
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