| Author | Charles S. Brennan, Ralph N. Martins |
| Publisher | John Wiley |
| Year | 2019 |
| Language | English |
| Pages | 532 |
| Size | book_size |
| Extension |
Summary
Neurodegeneration and Alzheimer's Disease: The Role of Diabetes, Genetics, Hormones, and Lifestyle is a meticulously researched and authoritative reference that delves deep into one of the most pressing public health concerns of our time: the rising incidence of neurodegenerative diseases. Drawing upon the latest advancements in neuroscience, molecular biology, and epidemiology, the authors explore how interconnected biological systems and lifestyle factors converge to influence brain health over a lifetime.
The book is structured to provide readers with a clear understanding of the pathological mechanisms underlying Alzheimer's disease, from amyloid-beta accumulation and tau protein dysfunction to mitochondrial impairment and neuroinflammation. A particularly unique aspect of this work is its dedicated focus on the link between type 2 diabetes and neurodegeneration—often referred to as "type 3 diabetes" in the scientific community—highlighting how insulin resistance and glucose dysregulation affect neuronal survival and cognitive performance.
In addition to examining genetic risk factors such as APOE ε4, the authors investigate the complex roles of sex hormones, stress hormones, and endocrine disruptors in brain aging. The final sections emphasize prevention and intervention strategies, including dietary patterns, exercise, cognitive stimulation, and emerging pharmacological therapies. With over 500 pages of evidence-based discussion, this book serves as both a scientific reference and a practical guide for clinicians, researchers, and informed readers interested in reducing the burden of Alzheimer’s disease.
Key Features
- Comprehensive coverage of the biochemical, genetic, and hormonal pathways involved in Alzheimer’s disease and other neurodegenerative disorders.
- Detailed analysis of the diabetes–Alzheimer’s connection, including insulin signaling in the brain.
- Up-to-date discussion of genetic susceptibility, including APOE genotype and emerging biomarkers.
- Insights into the roles of estrogen, testosterone, cortisol, and other hormones in cognitive decline.
- Evidence-based lifestyle recommendations for prevention and risk reduction.
- Contributions from leading experts in neuroscience, endocrinology, and geriatrics.
- Extensive reference lists and research summaries for further study.
About Author
Charles S. Brennan is a distinguished academic specializing in food science, nutrition, and functional foods, with a focus on how diet impacts metabolic health and chronic disease prevention. His multidisciplinary work bridges the gap between nutritional biochemistry and public health, making him a sought-after collaborator in international research initiatives.
Ralph N. Martins is a leading neuroscientist and Alzheimer’s researcher, renowned for his pioneering studies on amyloid-beta and oxidative stress. He has authored hundreds of peer-reviewed articles and is actively involved in developing diagnostic tools and preventive strategies for dementia. Martins’ work has significantly influenced both clinical approaches and public health policies regarding cognitive decline.
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Frequently Asked Questions
Q: What can I learn by reading this book?
A: You will gain an in-depth understanding of the biological, genetic, hormonal, and lifestyle factors that contribute to neurodegeneration and Alzheimer’s disease, as well as practical strategies for prevention and management.
Q: Is this book suitable for beginners?
A: While it contains advanced scientific content, the book is written in a way that motivated learners and healthcare students can follow with some background knowledge in biology or health sciences.
Q: Is this book recommended for professionals?
A: Absolutely. Clinicians, neuroscientists, nutritionists, and medical researchers will find it an invaluable resource for evidence-based practice and academic study.
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