Anne Ridley, Michelle Peckham, Peter Clark | ||||
Wiley | ||||
2004 | ||||
English | ||||
355 pages | ||||
3.94 MB | ||||
DJVU | ||||
[tab] [content title="Summary"]Cell Motility: From molecules to organisms [/content] [content title="Content"]Recent advancements in molecular and biophysical techniques, especially in fluorescence and live cell imaging, are transforming the study of cell motility. New bioprobes not only provide insights into intracellular localization but also reveal details about post-translational modifications, conformational states, and protein-protein interactions. By integrating these findings with complementary genetic and biochemical methods, researchers are gaining a deeper understanding of the mechanisms underlying cell motility—from molecular motors to in vivo cell movements across various organisms and cell types. This book presents landmark essays that offer a current and captivating overview of research and concepts in cell motility. Topics include the roles of molecular motors in driving movement and their interactions with the cytoskeleton, as well as membrane dynamics that facilitate cell shape changes and movement. Cell motility is crucial for development; chapters explore the genetics of cell migration, regulation of contact repulsion in growth cones, and the transition from cell migration to cell-cell adhesion. The book also addresses the directional nature of cell motility, with experts discussing the molecules that regulate chemotaxis, enabling cells to move along chemical gradients. Additionally, it examines how mutations can disrupt these processes, leading to metastasis when cells lose normal intercellular interactions and invade surrounding tissues. All these processes are modulated by environmental signals, including those from other tissues, and the molecules that transmit and translate these signals are thoroughly discussed. This book is essential reading for cell biologists across various fields—from development to wound healing—at all levels, including post-doctoral fellows, graduate students, and lab technicians. It is also a stimulating resource for molecular and developmental biologists, biophysicists, and biochemists. [/content] [content title="Author(s)"] [/content] [/tab]
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