Lipodomics and Bioactive Lipids : Lipids and Cell Signaling

	Author(s):	H. Alex Brown
	Collection:	Methods in Enzymology 434
	Publisher:	Elsevier, Academic Press
	Year:	2007
	Language:	English
	Pages:	392 pages
	Size:	3.54 MB
	Extension:	PDF

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[content title="Description"]This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Phospholipase A1 assays using a radio-labeled substrate and mass spectrometry; Real-time Cell Assays of Phospholipases A2 Using Fluorogenic Phospholipids; Analysis and Pharmacological Targeting of Phospholipase C ?? interactions with G proteins; Biochemical Analysis of Phospholipase D.; Measurement of Autotaxin/Lysophospholipase D Activity; Platelet-Activating Factor; Quantitative measurement of PtdIns(3,4,5)P3; Measuring Phosphorylated Akt And Other Phosphoinositide 3-Kinase-Regulated Phosphoproteins In Primary Lymphocytes; Regulation of Phosphatidylinositol 4-Phosphate 5-Kinase activity by partner proteins; Biochemical Analysis of Inositol Phosphate Kinases; Analysis of the phosphoinositides and their aqueous metabolites; Combination of C17-sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism; Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo; A rapid and sensitive method to measure secretion of sphingosine-1-phosphate; Ceramide Kinase and Ceramide-1-Phosphate; Measurement of Mammalian Diacylglycerol Kinase Activity in vitro and in Cells; Lipid Phosphate Phosphatases from Saccharomyces cerevisiae. [/content]

[content title="Content"] [/content]

[content title="About the author"]Alex grew up on the east coast of Florida close to the Kennedy Space Center. He attended Wake Forest University and received his Bachelor of Science with .. [/content]

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Debating Design : From Darwin to DNA

	Author(s):	William A. Dembski, Michael Ruse
	Collection:
	Publisher:	Cambridge University Press
	Year:	2007
	Language:	English
	Pages:	423 pages
	Size:	1.78 MB
	Extension:	PDF

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[content title="Description"]William Dembski, Michael Ruse, and other prominent philosophers provide here a comprehensive balanced overview of the debate concerning biological origins--a controversial dialectic since Darwin published The Origin of Species in 1859. Invariably, the source of controversy has been "design." Is the appearance of design in organisms (as exhibited in their functional complexity) the result of purely natural forces acting without prevision or teleology? Or, does the appearance of design signify genuine prevision and teleology, and, if so, is that design empirically detectable and thus open to scientific inquiry? Four main positions have emerged in response to these questions: *Darwinism* *self-organization* *theistic evolution* *intelligent design*. The contributors to this volume define their respective positions in an accessible style, inviting readers to draw their own conclusions. Two introductory essays furnish a historical overview of the debate. William A. Dembski is an associate research professor in the conceptual foundations of science at Baylor University as well as a senior fellow with Seattle's Discovery Institute. His most important books are The Design Inference Cambridge, 1998) and No Free Lunch (Rowman and Littleton, 2002). Michael Ruse is Lucyle T. Wekmeister Professor of Philosophy at Florida State University. He is the author of many books, including Can a Darwinian Be a Christian?: The Relationship Between Science and Religion (Cambridge, 2000).
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[content title="About the author"]William Albert Dembski (born July 18, 1960) is an American mathematician, philosopher and theologian. He was a proponent of intelligent design (ID) pseudoscience, specifically the concept of specified complexity, and was a senior fellow of the Discovery Institute's Center for Science and Culture (CSC). [/content]

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Canonical Perturbation Theories : Degenerate Systems and Resonance

	Author(s):	Sylvio Ferraz-Mello
	Collection:	Astrophysics and Space Science Library 345
	Publisher:	Springer-Verlag New York
	Year:	2007
	Language:	English
	Pages:	350 pages
	Size:	3.92 MB
	Extension:	PDF

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[content title="Description"]Canonical Perturbation Theories, Degenerate Systems and Resonance presents the foundations of Hamiltonian Perturbation Theories used in Celestial Mechanics, emphasizing the Lie Series Theory and its application to degenerate systems and resonance.

This book is the complete text on the subject including advanced topics in Hamiltonian Mechanics, Hori’s Theory, and the classical theories of Poincaré, von Zeipel-Brouwer, and Delaunay. Also covered are Kolmogorov’s frequency relocation method to avoid small divisors, the construction of action-angle variables for integrable systems, and a complete overview of some problems in Classical Mechanics.

Sylvio Ferraz-Mello makes these ideas accessible not only to Astronomers, but also to those in the related fields of Physics and Mathematics. [/content]

[content title="Content"] [/content]

[content title="About the author"]Sylvio Ferraz Mello
Astronomer

Teaching : University of Paris
Books : Canonical Perturbation Theories: Degenerate Systems and Resonance

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Lipodomics and Bioactive Lipids : Lipids and Cell Signaling

	Author(s):	H. Alex Brown
	Collection:	Methods in Enzymology 434
	Publisher:	Elsevier, Academic Press
	Year:	2007
	Language:	English
	Pages:	392 pages
	Size:	3.54 MB
	Extension:	PDF

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[content title="Description"]This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Phospholipase A1 assays using a radio-labeled substrate and mass spectrometry; Real-time Cell Assays of Phospholipases A2 Using Fluorogenic Phospholipids; Analysis and Pharmacological Targeting of Phospholipase C ?? interactions with G proteins; Biochemical Analysis of Phospholipase D.; Measurement of Autotaxin/Lysophospholipase D Activity; Platelet-Activating Factor; Quantitative measurement of PtdIns(3,4,5)P3; Measuring Phosphorylated Akt And Other Phosphoinositide 3-Kinase-Regulated Phosphoproteins In Primary Lymphocytes; Regulation of Phosphatidylinositol 4-Phosphate 5-Kinase activity by partner proteins; Biochemical Analysis of Inositol Phosphate Kinases; Analysis of the phosphoinositides and their aqueous metabolites; Combination of C17-sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism; Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo; A rapid and sensitive method to measure secretion of sphingosine-1-phosphate; Ceramide Kinase and Ceramide-1-Phosphate; Measurement of Mammalian Diacylglycerol Kinase Activity in vitro and in Cells; Lipid Phosphate Phosphatases from Saccharomyces cerevisiae. [/content]

[content title="Content"] [/content]

[content title="About the author"]The scientific community suffered a great loss on July 25, when H. Alex Brown passed away at the age of 56 after a long battle with an aggressive cancer. True to everything that Alex was, he retained his focus on science, his love and pride in his family, and an incredibly positive outlook throughout his treatment. [/content]

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Stem Cells in the Respiratory System

	Author(s):	Susan D. Reynolds, Moumita Ghosh,Mauricio Rojas
	Collection:	Stem Cell Biology and Regenerative Medicine
	Publisher:	Humana Press
	Year:	2010
	Language:	English
	Pages:	177 pages
	Size:	2.38 MB
	Extension:	PDF

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[content title="Description"]In this state-of-the-art exploration of a hugely dynamic and fast-evolving field of research, leading researchers share their collective wisdom on the role that stem cells could play in the context of physiological stress and lung injury. The text focuses on reviewing the most relevant—and recent—ideas on using local, endogenous, and exogenous progenitor/stem cells in preventing and treating injury to the lung. The lungs are one of the most complex organs in the human body, with a mature adult lung boasting at least 40 morphologically differentiated cell lineages. Our entire blood supply passes through the lung’s alveolar units during oxygenation. This interaction with the outside world, along with the intricacies of its structure, makes the lung a highly susceptible organ that is vulnerable to numerous types of injury and infection. This means that the mechanisms of lung repair are in themselves correspondingly complex. Because of their multipotentiality, as well as the fact of the lung’s relatively rapid cell turnover, stem cells are thought to be an important alternative cell-base therapy in lung injury. Despite the controversial nature of stem cell research, there has been growing interest in both local and endogenous stem cells in the lung. This highly topical book with chapters on everything from using mesenchymal stem cells in lung repair to the effect of physical activity on the mobilization of stem and progenitor cells, represents an exciting body of work by outstanding investigators and will be required reading for those with an interest in the subject.

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[content title="About the author"]Susan D. Reynolds, PhD's research focuses on tissue stem cells that maintain the conducting airway epithelium. Previous work identified a basal cell subtype that functioned as a tissue stem cell in mice. Current research translates these findings to human airways and seeks to use the tissue stem cell as therapy for lung disease, including Cystic Fibrosis. [/content]

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Phosphoinositide 3-kinase in Health and Disease -Volume 1

	Author(s):	Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt
	Collection:	Current Topics in Microbiology and Immunology, Volume 346
	Publisher:	Springer
	Year:	2010
	Language:	English
	Pages:	318 pages
	Size:	4.47 MB
	Extension:	PDF

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[content title="Description"]PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone
The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being closely monitored; however, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here. [/content]

[content title="Content"] [/content]

[content title="About the author"]Christian Rommel became Executive Vice
President, Global Head of Research &
Development and a member of the executive
committee of Bayer Pharmaceuticals in
February 2021. He joined Bayer from Roche,
where he was most recently Senior Vice
President, Global Head of Oncology, Pharma
Research and Early Development (pRED).
Before that, Christian worked at Amgen where
he held roles such as Vice President of
External Research and Development and Vice President, Research Oncology.
Previously, Christian served as Chief Scientific Officer of Intellikine from its inception
to acquisition by Takeda. [/content]

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Biosystems Engineering I : Creating Superior Biocatalysts

	Author(s):	Sang Yup Lee, Jin Hwan,Christoph Wittmann, Rainer Krull
	Collection:	Advances in Biochemical Engineering Biotechnology 120
	Publisher:	Springer-Verlag Berlin Heidelberg
	Year:	2010
	Language:	English
	Pages:	262 pages
	Size:	2.94 MB
	Extension:	PDF

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[content title="Description"]-Integration of Systems Biology with Bioprocess Engineering: L-Threonine Production by Systems Metabolic Engineering of Escherichia Coli, By Sang Yup Lee and Jin Hwan Park; -Analysis and Engineering of Metabolic Pathway Fluxes in Corynebacterium glutamicum, By Christoph Wittmann; -Systems Biology of Industrial Microorganisms, Marta Papini, Margarita Salazar, and Jens Nielsen; -De Novo Metabolic Engineering and the Promise of Synthetic DNA, By Daniel Klein-Marcuschamer, Vikramaditya G. Yadav, Adel Ghaderi, and Gregory N. Stephanopoulos; -Systems Biology of Recombinant Protein Production in Bacillus megaterium, Rebekka Biedendieck, Boyke Bunk, Tobias Fürich, Ezequiel Franco-Lara, Martina Jahn, and Dieter Jahn; -Extending Synthetic Routes for Oligosaccharides by Enzyme, Substrate and Reaction Engineering; By Jürgen Seibel, Hans-Joachim Jördening, and Klaus Buchholz; -Regeneration of Nicotinamide Coenzymes: Principles and Applications for the Synthesis of Chiral Compounds; By Andrea Weckbecker, Harald Gröger, and Werner Hummel;

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[content title="About the author"]Sang Yup Lee is an American-based Korean-born industrial designer. In 1995 he came to America to study Transportation design at the Art Center in Pasadena. He would later take a job with Porsche and Pininfarina in Europe before moving back stateside to work at General Motors.Professor and Director of Institute for Systems Biotechnology
Saarland University
At present, Christoph Wittmann is professor and director of the Institute of Systems Biotechnology at Saarland University, Saarbrücken. Prior to his current position, he received his PhD in biotechnology at the German Research Institute for Biotechnology (GBF) in Braunschweig, was postdoc at the University of Helsinki, professor for biotechnology at Münster University, professor and director of the Institute of Biochemical Engineering, as well as co-founder of the Systems Biology Centre and the Centre for Pharmaceutical Engineering at Braunschweig Technical University in Germany.
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Immunology and Immunopathogenesis of Malaria

	Author(s):	Jean Langhorne
	Collection:	Current Topics in Microbiology and Immunology
	Publisher:	Springer
	Year:	2005
	Language:	English
	Pages:	239 pages
	Size:	1.39 MB
	Extension:	PDF

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[content title="Description"]Malaria is still a major global health problem, killing more than 1 million people every year. Almost all of these deaths are caused by Plasmodium falciparum, one of the four species of malaria parasites infecting humans. This high burden of mortality falls heavily on Sub-Saharan Africa, where over 90% of these deaths are thought to occur, and 5% of children die before the age of 5 years. The death toll from malaria is still growing, with malaria-specific mortality in young African children estimated to have doubled during the last twenty years. This increase has been associated with drug resistance of the parasite, spread of insecticide resistant mosquitoes, poverty, social and political upheaval, and lack of effective vaccines. This collection of reviews addresses many of these important issues of malarial immunity and immunopathology. They are of interest not only to malariologists, but hopefully also to the broader immunological community. Strong interactions with, and feedback from immunologists working in other infectious diseases and in basic immunology will help us to move the field of malaria immunology and therapeutic intervention forward more quickly.
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[content title="About the author"]Jean Langhorne is a group leader at the Francis Crick Institute. She obtained her BSc at Bedford College, University of London, and an MSc at the London School of Hygiene and Tropical Medicine.

After her PhD at the Medical Research Council (MRC) Clinical Research Centre, London UK, she carried out postdoctoral training in immunology of malaria with Sydney Cohen at Guy's Hospital Medical School, London, and then moved to the Basel institute for Immunology, Switzerland.

She was awarded a Fogarty fellowship to join the National Institute of Allergy and Infectious Diseases/National Institutes of Health in the USA. After four years she moved to the Max Planck Institute in Freiburg, Germany, to establish her own group. [/content]

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The Liberation of Life : From the Cell to the Community

	Author(s):	Charles Birch, John B. Cobb
	Collection:
	Publisher:
	Year:	1982
	Language:	English
	Pages:	368 pages
	Size:	2.67 MB
	Extension:	DJVU

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[content title="Description"]This book is about the liberation of the concept of life from the bondage fashioned by the interpreters of life ever since biology began, and about the liberation of the life of humans and non-humans alike from the bondage of social structures and behaviour, which now threatens the fullness of life's possibilities if not survival itself. It falls into a tradition of writings about human problems from a perspective informed by biology. It rejects the mechanistic model of life dominant in the Western world and develops an alternative 'ecological model' which is applicable to the life of the cell and the life of the human community. For the first time it brings together in one work the insights of modern biology with those of a modern holistic philosophy and a liberal theology in a way which challenges conventional approaches to science, agriculture, sociology, politics, economics, development and liberation movements.
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[content title="About the author"]Louis Charles Birch FAA (1918–2009) was an Australian geneticist specialising in population ecology and was also well known as a theologian, writing widely on the topic of science and religion, winning the Templeton Prize in 1990. The prize recognised his work ascribing intrinsic value to all life. (born 9 February 1925) is an American theologian, philosopher, and environmentalist. Cobb is often regarded as the preeminent scholar in the field of process philosophy and process theology, the school of thought associated with the philosophy of Alfred North Whitehead. Cobb is the author of more than fifty books.

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Biologie du développement - 7e édition

	Auteur(s):	Albert Le Moigne, Jean Foucrier
	Collection:	Sciences Sup
	Editeur:	Dunod
	Année:	18/06/2009
	Langue:	Français
	Pages:	435 pages
	Taille:	10.4 MB
	Extension:	PDF

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[content title="Description"]Cet ouvrage décrit les principales étapes du développement des êtres vivants et leur mécanisme : gamétogenèse et fécondation, embryogenèse, morphogenèse. Le modèle d'étude privilégié est la Drosophile. Cette 7e édition a été entièrement revue et actualisée pour tenir compte des derniers apports de la biologie moléculaire. Des encarts techniques et médicaux ont été ajoutés, ainsi que des questions de révision en fin de chapitre. [/content]

[content title="Sommaire"]

• GAMETOGENESE ET FECONDATION
  • Généralités sur la gamétogenèse, la méiose
  • Spermatogenèse
  • Ovogenèse
• EMBRYOLOGIE DESCRIPTIVE
  • Développement de l'oursin
  • Développement d'un insecte
  • Développement des Amphibiens
• MECANISMES DE LA MORPHOGENESE
  • Contrôle génétique du développement
  • Analyse de la segmentation
  • Mouvements morphogénétiques et leur coordination

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[content title="Auteur(s) de l'ouvrage"]

Albert Le Moigne est professeur honoraire de l'université Paris XII Val-de-Marne.

Jean Foucrier est professeur à l'université Paris XII Val-de-Marne.

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